Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites()

S-adenosyl-l-methionine decarboxylase (AdoMetDC) in the polyamine biosynthesis pathway has been identified as a suitable drug target in Plasmodium falciparum parasites, which causes the most lethal form of malaria. Derivatives of an irreversible inhibitor of this enzyme, 5′-{[(Z)-4-amino-2-butenyl]m...

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Main Authors: le Roux, Dina, Burger, Pieter B., Niemand, Jandeli, Grobler, Anne, Urbán, Patricia, Fernàndez-Busquets, Xavier, Barker, Robert H., Serrano, Adelfa E., I. Louw, Abraham, Birkholtz, Lyn-Marie
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940083/
https://ncbi.nlm.nih.gov/pubmed/24596666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2013.11.003
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