Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan.
Thiorphan, N-[(R,S)-3-mercapto-2-benzylpropanoyl]glycine is a highly potent inhibitor (Ki = 3.5 nM) of "enkephalinase," a metalloendopeptidase cleaving the Gly-Phe bond (positions 3 and 4) of enkephalins in brain tissue. In accordance with this property, thiorphan displays antinociceptive activity a...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
1983
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394003/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6304695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.11.3178 |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|