Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan.

Thiorphan, N-[(R,S)-3-mercapto-2-benzylpropanoyl]glycine is a highly potent inhibitor (Ki = 3.5 nM) of "enkephalinase," a metalloendopeptidase cleaving the Gly-Phe bond (positions 3 and 4) of enkephalins in brain tissue. In accordance with this property, thiorphan displays antinociceptive activity a...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Roques, B P, Lucas-Soroca, E, Chaillet, P, Costentin, J, Fournié-Zaluski, M C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1983
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394003/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6304695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.11.3178
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