LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo

OBJECTIVE: Impaired amyloid clearance has been proposed to contribute to β-amyloid deposition in sporadic late-onset Alzheimer's disease (AD). Low density lipoprotein receptor-related protein 1 (LRP-1) is involved in the active outward transport of β-amyloid across the blood–brain barrier (BBB)...

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Main Authors: Grimmer, Timo, Goldhardt, Oliver, Guo, Liang-Hao, Yousefi, Behrooz H., Förster, Stefan, Drzezga, Alexander, Sorg, Christian, Alexopoulos, Panagiotis, Förstl, Hans, Kurz, Alexander, Perneczky, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939495/
https://ncbi.nlm.nih.gov/pubmed/24596678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nicl.2014.01.016
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