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Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification
Centrosome duplication is licensed by the disengagement, or ‘uncoupling’, of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature disengagement results from untimely activation of the APC/C leading to securin degra...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3939426/ https://ncbi.nlm.nih.gov/pubmed/22956538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.106096 |
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