Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL) is an accumulative disorder marked by deficient apoptosis. The TP53 homolog TAp63 promotes apoptosis and chemosensitivity in solid tumours and its deregulation may contribute to CLL cell survival. We found that TAp63α was the most prevalent TP63 isoform in CLL. Co...

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Bibliografiske detaljer
Main Authors: Humphries, Leigh A., Godbersen, J. Claire, Danilova, Olga V., Kaur, Prabhjot, Christensen, Brock C., Danilov, Alexey V.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939033/
https://ncbi.nlm.nih.gov/pubmed/24117128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12580
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