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De Novo Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors
Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2) maintains gene repres...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938834/ https://ncbi.nlm.nih.gov/pubmed/24587223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090095 |
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