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NMR Characterization of the Near Native and Unfolded States of the PTB Domain of Dok1: Alternate Conformations and Residual Clusters

BACKGROUND: Phosphotyrosine binding (PTB) domains are critically involved in cellular signaling and diseases. PTB domains are categorized into three distinct structural classes namely IRS-like, Shc-like and Dab-like. All PTB domains consist of a core pleckstrin homology (PH) domain with additional s...

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Bibliographische Detailangaben
Hauptverfasser: Gupta, Sebanti, Bhattacharjya, Surajit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938774/
https://ncbi.nlm.nih.gov/pubmed/24587391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090557
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