IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model

BACKGROUND: IL-17 is the defining cytokine of the Th17, Tc17, and γδ T cell populations that plays a critical role in mediating inflammation and autoimmunity. Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines with relevant contributions of IFN-γ, TNF-α, and IL-17....

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Main Authors: Chiricozzi, Andrea, Nograles, Kristine E., Johnson-Huang, Leanne M., Fuentes-Duculan, Judilyn, Cardinale, Irma, Bonifacio, Kathleen M., Gulati, Nicholas, Mitsui, Hiroshi, Guttman-Yassky, Emma, Suárez-Fariñas, Mayte, Krueger, James G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938679/
https://ncbi.nlm.nih.gov/pubmed/24587313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090284
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