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Pam (Peptidylglycine α-amidating monooxygenase) heterozygosity alters brain copper handling with region specificity

Copper (Cu), an essential trace element present throughout the mammalian nervous system, is crucial for normal synaptic function. Neuronal handling of Cu is poorly understood. We studied the localization and expression of Atp7a, the major intracellular Cu transporter in the brain, and its relation t...

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Autors principals: Gaier, Eric D, Miller, Megan B, Ralle, Martina, Aryal, Dipendra, Wetsel, William C, Mains, Richard E, Eipper, Betty A
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938575/
https://ncbi.nlm.nih.gov/pubmed/24032518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12438
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