Pam (Peptidylglycine α-amidating monooxygenase) heterozygosity alters brain copper handling with region specificity

Copper (Cu), an essential trace element present throughout the mammalian nervous system, is crucial for normal synaptic function. Neuronal handling of Cu is poorly understood. We studied the localization and expression of Atp7a, the major intracellular Cu transporter in the brain, and its relation t...

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Autori principali: Gaier, Eric D, Miller, Megan B, Ralle, Martina, Aryal, Dipendra, Wetsel, William C, Mains, Richard E, Eipper, Betty A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938575/
https://ncbi.nlm.nih.gov/pubmed/24032518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12438
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