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Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. In addition to binding to NMDA receptors, dextromethorphan...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938562/ https://ncbi.nlm.nih.gov/pubmed/24587167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089985 |
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