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Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target
Protein phosphatase methylesterase 1 (PPME1) is a protein phosphatase 2A (PP2A)-specific methyl esterase that negatively regulates PP2A through demethylation at its carboxy terminal leucine 309 residue. Emerging evidence shows that the upregulation of PPME1 is associated with poor prognosis in gliob...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938515/ https://ncbi.nlm.nih.gov/pubmed/24253382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.27146 |
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