Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes

AIMS/HYPOTHESIS: Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular mechanism by which PD1 signaling protects from type 1 diabetes is not clear. We hy...

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Detalhes bibliográficos
Main Authors: Kochupurakkal, Nora M., Kruger, Annie J., Tripathi, Sudipta, Zhu, Bing, Adams, La Tonya, Rainbow, Daniel B., Rossini, Aldo, Greiner, Dale L., Sayegh, Mohamed H., Wicker, Linda S., Guleria, Indira
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938467/
https://ncbi.nlm.nih.gov/pubmed/24586872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089561
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