Abrogation of Rbpj Attenuates Experimental Autoimmune Uveoretinitis by Inhibiting IL-22-Producing CD4(+) T Cells

Experimental autoimmune uveoretinitis (EAU) is an organ-specific T cell-mediated disease induced by immunizing mice with interphotoreceptor retinoid binding protein (IRBP). Autoaggressive CD4(+) T cells are the major pathogenic population for EAU. We investigated the contribution of Notch signaling...

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Detalhes bibliográficos
Main Authors: Bhuyan, Zaied Ahmed, Asanoma, Michihito, Iwata, Akiko, Ishifune, Chieko, Maekawa, Yoichi, Shimada, Mitsuo, Yasutomo, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938452/
https://ncbi.nlm.nih.gov/pubmed/24586644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089266
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