"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

A beta+-thalassemia globin gene was isolated from the genome of a Black individual by molecular cloning. DNA sequence analysis revealed only a single difference between this gene and the normal human beta-globin gene--adenine is substituted for thymine in the third position of codon 24. Codon 24 in...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Goldsmith, M E, Humphries, R K, Ley, T, Cline, A, Kantor, J A, Nienhuis, A W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1983
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393811/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.8.2318
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