"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

A beta+-thalassemia globin gene was isolated from the genome of a Black individual by molecular cloning. DNA sequence analysis revealed only a single difference between this gene and the normal human beta-globin gene--adenine is substituted for thymine in the third position of codon 24. Codon 24 in...

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Bibliographic Details
Main Authors: Goldsmith, M E, Humphries, R K, Ley, T, Cline, A, Kantor, J A, Nienhuis, A W
Format: Artigo
Language:Inglês
Published: 1983
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC393811/
https://ncbi.nlm.nih.gov/pubmed/6572978
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