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"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

A beta+-thalassemia globin gene was isolated from the genome of a Black individual by molecular cloning. DNA sequence analysis revealed only a single difference between this gene and the normal human beta-globin gene--adenine is substituted for thymine in the third position of codon 24. Codon 24 in...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Goldsmith, M E, Humphries, R K, Ley, T, Cline, A, Kantor, J A, Nienhuis, A W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1983
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393811/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572978/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.8.2318
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