Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels

Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. PI4KA has also been linked to endoplasmic reticulum exit sites and generation of plasma membrane phosphoinositides. Here, we developed highly speci...

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Autori principali: Bojjireddy, Naveen, Botyanszki, Janos, Hammond, Gerald, Creech, Donald, Peterson, Richard, Kemp, Daniel C., Snead, Mark, Brown, Randy, Morrison, Alastair, Wilson, Steve, Harrison, Steve, Moore, Chris, Balla, Tamas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937678/
https://ncbi.nlm.nih.gov/pubmed/24415756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.531426
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