Activation of the Prereplication Complex Is Blocked by Mimosine through Reactive Oxygen Species-activated Ataxia Telangiectasia Mutated (ATM) Protein without DNA Damage

Mimosine is an effective cell synchronization reagent used for arresting cells in late G(1) phase. However, the mechanism underlying mimosine-induced G(1) cell cycle arrest remains unclear. Using highly synchronous cell populations, we show here that mimosine blocks S phase entry through ATM activat...

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Autors principals: Kubota, Shoichi, Fukumoto, Yasunori, Ishibashi, Kenichi, Soeda, Shuhei, Kubota, Sho, Yuki, Ryuzaburo, Nakayama, Yuji, Aoyama, Kazumasa, Yamaguchi, Noritaka, Yamaguchi, Naoto
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937646/
https://ncbi.nlm.nih.gov/pubmed/24421316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.546655
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