The methyltransferase G9a regulates HoxA9-dependent transcription in AML

Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological inhibition. Here we establish the histone methyltransferase G9a/EHMT2 as a selective regulator of fast proliferating myeloid progenitors with no dis...

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Autors principals: Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T. Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R. Keith, Rossi, Fabio M.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937511/
https://ncbi.nlm.nih.gov/pubmed/24532712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.236794.113
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