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Targeting human CD27 with an agonist antibody stimulates T-cell activation and antitumor immunity
CD27 is an important co-stimulatory receptor of T cells that can potentially be exploited for immunotherapy. We developed a human IgG1 antibody that targets human CD27, and demonstrated its immunostimulatory and antineoplastic activity in various preclinical models. Currently, the antibody (1F5, CDX...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937191/ https://ncbi.nlm.nih.gov/pubmed/24605266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.27255 |
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