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Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice
BACKGROUND: Sildenafil is a selective PDE5 inhibitor that increases cGMP levels in the target tissues and is an effective treatment agent for erectile dysfunction. The nitric oxide-cGMP pathway might be implicated in regulation of certain CNS functions, including locomotor activity and anxiety. MATE...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Scientific Literature, Inc.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936918/ https://ncbi.nlm.nih.gov/pubmed/24500039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSMBR.890280 |
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