Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis

The U1 small nuclear ribonucleoprotein (snRNP) plays pivotal roles in pre-mRNA splicing and in regulating mRNA length and isoform expression; however, the mechanism of U1 snRNA quality control remains undetermined. Here, we describe a novel surveillance pathway for U1 snRNP biogenesis. Mass spectrom...

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Bibliographische Detailangaben
Hauptverfasser: Ishikawa, Hideaki, Nobe, Yuko, Izumikawa, Keiichi, Yoshikawa, Harunori, Miyazawa, Naoki, Terukina, Goro, Kurokawa, Natsuki, Taoka, Masato, Yamauchi, Yoshio, Nakayama, Hiroshi, Isobe, Toshiaki, Takahashi, Nobuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936765/
https://ncbi.nlm.nih.gov/pubmed/24311566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1271
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