CD73-Dependent Generation of Adenosine and Endothelial Adora2b Signaling Attenuate Diabetic Nephropathy

Nucleotide phosphohydrolysis by the ecto-5′-nucleotidase (CD73) is the main source for extracellular generation of adenosine. Extracellular adenosine subsequently signals through four distinct adenosine A receptors (Adora1, Adora2a, Adora2b, or Adora3). Here, we hypothesized a functional role for CD...

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Autores principales: Tak, Eunyoung, Ridyard, Douglas, Kim, Jae-Hwan, Zimmerman, Michael, Werner, Tilmann, Wang, Xiaoxin X., Shabeka, Uladzimir, Seo, Seong-Wook, Christians, Uwe, Klawitter, Jost, Moldovan, Radu, Garcia, Gabriela, Levi, Moshe, Haase, Volker, Ravid, Katya, Eltzschig, Holger K., Grenz, Almut
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2014
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935577/
https://ncbi.nlm.nih.gov/pubmed/24262796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012101014
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