DNA sequence changes in an upstream DNase I-hypersensitive region are correlated with reduced gene expression.

Previous experiments have identified a region that is required for the expression of the Drosophila glue protein gene Sgs-4 and is located 300-500 base pairs upstream from the structural gene. The chromatin in this region changes conformation and becomes hypersensitive to DNase I digestion when the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	McGinnis, W, Shermoen, A W, Heemskerk, J, Beckendorf, S K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1983
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6405379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.4.1063
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