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Astrocyte-derived Endothelin-1 inhibits remyelination through Notch activation
Oligodendrocyte progenitor cells (OPCs) can repair demyelinated lesions by maturing into myelin-producing oligodendrocytes. However, the OPC potential to differentiate can be prevented by inhibitory signals present in the pathological lesion environment. Identification of these signals is essential...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935216/ https://ncbi.nlm.nih.gov/pubmed/24507193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.11.015 |
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