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Asynchronous Evolutionary Origins of Aβ and BACE1
Neurodegenerative plaques characteristic of Alzheimer’s disease (AD) are composed of amyloid beta (Aβ) peptide, which is proteolyzed from amyloid precursor protein (APP) by β-secretase (beta-site APP cleaving enzyme [BACE1]) and γ-secretase. Although γ-secretase has essential functions across metazo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935185/ https://ncbi.nlm.nih.gov/pubmed/24361992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst262 |
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