Asynchronous Evolutionary Origins of Aβ and BACE1

Neurodegenerative plaques characteristic of Alzheimer’s disease (AD) are composed of amyloid beta (Aβ) peptide, which is proteolyzed from amyloid precursor protein (APP) by β-secretase (beta-site APP cleaving enzyme [BACE1]) and γ-secretase. Although γ-secretase has essential functions across metazo...

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Autors principals: Moore, D. Blaine, Gillentine, Madelyn A., Botezatu, Nathalie M., Wilson, Kyle A., Benson, Ashley E., Langeland, James A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Discoveries
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935185/
https://ncbi.nlm.nih.gov/pubmed/24361992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst262
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