Rare Human Nicotinic Acetylcholine Receptor α4 Subunit (CHRNA4) Variants Affect Expression and Function of High-Affinity Nicotinic Acetylcholine Receptors

Nicotine, the primary psychoactive component in tobacco smoke, produces its behavioral effects through interactions with neuronal nicotinic acetylcholine receptors (nAChRs). α4β2 nAChRs are the most abundant in mammalian brain, and converging evidence shows that this subtype mediates the rewarding a...

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Autors principals: McClure-Begley, T. D., Papke, R. L., Stone, K. L., Stokes, C., Levy, A. D., Gelernter, J., Xie, P., Lindstrom, J., Picciotto, M. R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2014
Matèries:
Cellular and Molecular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935145/
https://ncbi.nlm.nih.gov/pubmed/24385388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.209767
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