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Increased Actin Polymerization and Stabilization Interferes with Neuronal Function and Survival in the AMPKγ Mutant Loechrig

loechrig (loe) mutant flies are characterized by progressive neuronal degeneration, behavioral deficits, and early death. The mutation is due to a P-element insertion in the gene for the γ-subunit of the trimeric AMP-activated protein kinase (AMPK) complex, whereby the insertion affects only one of...

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Detalhes bibliográficos
Main Authors: Cook, Mandy, Bolkan, Bonnie J., Kretzschmar, Doris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934941/
https://ncbi.nlm.nih.gov/pubmed/24587072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089847
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