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Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
Starting from the primary structure of sunflower trypsin inhibitor SFTI-1, we designed novel non-covalent inhibitors of human and yeast 20S proteasomes. Peptides with Arg residue in P(1) position and two basic amino acid residues (Lys or/and Arg) in P(2)′ and P(3)′ positions strongly inhibited chymo...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3934894/ https://ncbi.nlm.nih.gov/pubmed/24586798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089465 |
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