Normalization of RNA-Sequencing Data from Samples with Varying mRNA Levels

Methods for normalization of RNA-sequencing gene expression data commonly assume equal total expression between compared samples. In contrast, scenarios of global gene expression shifts are many and increasing. Here we compare the performance of three normalization methods when polyA(+) RNA content...

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Bibliographic Details
Main Authors: Aanes, Håvard, Winata, Cecilia, Moen, Lars F., Østrup, Olga, Mathavan, Sinnakaruppan, Collas, Philippe, Rognes, Torbjørn, Aleström, Peter
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934880/
https://ncbi.nlm.nih.gov/pubmed/24586560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089158
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