5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy

The transcriptome is subject to multiple changes during pathogenesis, including the use of alternate 5′ start-sites that can affect transcription levels and output. Current RNA sequencing techniques can assess mRNA levels, but do not robustly detect changes in 5′ start-site use. Here, we developed a...

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Main Authors: Christodoulou, Danos C., Wakimoto, Hiroko, Onoue, Kenji, Eminaga, Seda, Gorham, Joshua M., DePalma, Steve R., Herman, Daniel S., Teekakirikul, Polakit, Conner, David A., McKean, David M., Domenighetti, Andrea A., Aboukhalil, Anton, Chang, Stephen, Srivastava, Gyan, McDonough, Barbara, De Jager, Philip L., Chen, Ju, Bulyk, Martha L., Muehlschlegel, Jochen D., Seidman, Christine E., Seidman, J.G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2014
Ábhair:
Technical Advance
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934171/
https://ncbi.nlm.nih.gov/pubmed/24509080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70108
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