5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy

The transcriptome is subject to multiple changes during pathogenesis, including the use of alternate 5′ start-sites that can affect transcription levels and output. Current RNA sequencing techniques can assess mRNA levels, but do not robustly detect changes in 5′ start-site use. Here, we developed a...

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Autori principali: Christodoulou, Danos C., Wakimoto, Hiroko, Onoue, Kenji, Eminaga, Seda, Gorham, Joshua M., DePalma, Steve R., Herman, Daniel S., Teekakirikul, Polakit, Conner, David A., McKean, David M., Domenighetti, Andrea A., Aboukhalil, Anton, Chang, Stephen, Srivastava, Gyan, McDonough, Barbara, De Jager, Philip L., Chen, Ju, Bulyk, Martha L., Muehlschlegel, Jochen D., Seidman, Christine E., Seidman, J.G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
Soggetti:
Technical Advance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934171/
https://ncbi.nlm.nih.gov/pubmed/24509080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70108
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