Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer’s-like cognitive decline

Cognitive decline in patients with Alzheimer’s disease (AD) is associated with elevated brain levels of amyloid β protein (Aβ), particularly neurotoxic Aβ(1–42). Angiotensin-converting enzyme (ACE) can degrade Aβ(1–42), and ACE overexpression in myelomonocytic cells enhances their immune function. T...

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Autors principals: Bernstein, Kenneth E., Koronyo, Yosef, Salumbides, Brenda C., Sheyn, Julia, Pelissier, Lindsey, Lopes, Dahabada H.J., Shah, Kandarp H., Bernstein, Ellen A., Fuchs, Dieu-Trang, Yu, Jeff J.-Y., Pham, Michael, Black, Keith L., Shen, Xiao Z., Fuchs, Sebastien, Koronyo-Hamaoui, Maya
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934162/
https://ncbi.nlm.nih.gov/pubmed/24487585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66541
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