Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease

Targeted overexpression of angiotensin-converting enzyme (ACE), an amyloid-β protein degrading enzyme, to brain resident microglia and peripheral myelomonocytes (ACE(10) model) substantially diminished Alzheimer’s-like disease in double-transgenic APP(SWE)/PS1(ΔE9) (AD(+)) mice. In this study, we ex...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Koronyo-Hamaoui, Maya, Sheyn, Julia, Hayden, Eric Y, Li, Songlin, Fuchs, Dieu-Trang, Regis, Giovanna C, Lopes, Dahabada H J, Black, Keith L, Bernstein, Kenneth E, Teplow, David B, Fuchs, Sebastien, Koronyo, Yosef, Rentsendorj, Altan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935752/
https://ncbi.nlm.nih.gov/pubmed/31794021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz364
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