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Nicotinamide: a Class III HDACi Delays In Vitro Aging of Mouse Oocytes

Postovulatory mammalian oocyte developmental potential decreases with aging in vivo and in vitro. Aging oocytes typically show cellular fragmentation and chromosome scattering with an abnormally shaped spindle over time. Previously, it was shown that histone acetylation in the mouse oocyte increased...

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Autors principals: LEE, Ah Reum, KISHIGAMI, Satoshi, AMANO, Tomoko, MATSUMOTO, Kazuya, WAKAYAMA, Teruhiko, HOSOI, Yoshihiko
Format: Artigo
Idioma:Inglês
Publicat: The Society for Reproduction and Development 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934134/
https://ncbi.nlm.nih.gov/pubmed/23474603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1262/jrd.2012-171
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