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Ipilimumab in the treatment of metastatic melanoma: management of adverse events
Recently, “ipilimumab,” an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. “CTLA-4” is an immune-checkpoint molecule that downregulates pathways of T-cell activation. Ipilimumab, by targeting CTLA-4, is abl...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Dove Medical Press
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3933725/ https://ncbi.nlm.nih.gov/pubmed/24570590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S57335 |
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