Oncogenic H-Ras Up-Regulates Acid β-Hexosaminidase by a Mechanism Dependent on the Autophagy Regulator TFEB

The expression of constitutively active H-RasV12 oncogene has been described to induce proliferative arrest and premature senescence in many cell models. There are a number of studies indicating an association between senescence and lysosomal enzyme alterations, e.g. lysosomal β-galactosidase is the...

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Detalhes bibliográficos
Main Authors: Urbanelli, Lorena, Magini, Alessandro, Ercolani, Luisa, Sagini, Krizia, Polchi, Alice, Tancini, Brunella, Brozzi, Alessandro, Armeni, Tatiana, Principato, Giovanni, Emiliani, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933543/
https://ncbi.nlm.nih.gov/pubmed/24586816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089485
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