High-Throughput Screening Identifies Idarubicin as a Preferential Inhibitor of Smooth Muscle versus Endothelial Cell Proliferation

Intimal hyperplasia is the cause of the recurrent occlusive vascular disease (restenosis). Drugs currently used to treat restenosis effectively inhibit smooth muscle cell (SMC) proliferation, but also inhibit the growth of the protective luminal endothelial cell (EC) lining, leading to thrombosis. T...

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Detalhes bibliográficos
Main Authors: Goel, Shakti A., Guo, Lian-Wang, Wang, Bowen, Guo, Song, Roenneburg, Drew, Ananiev, Gene E., Hoffmann, F. Michael, Kent, K. Craig
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933427/
https://ncbi.nlm.nih.gov/pubmed/24586708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089349
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