A Palindromic CpG-Containing Phosphodiester Oligodeoxynucleotide as a Mucosal Adjuvant Stimulates Plasmacytoid Dendritic Cell-Mediated T(H)1 Immunity

BACKGROUND: CpG oligodeoxynucleotides (ODNs), resembling bacterial DNA, are currently tested in clinical trials as vaccine adjuvants. They have the nuclease-resistant phosphorothioate bond; the immune responses elicited differ according to the CpG ODN sequence and vaccination method. To develop a Cp...

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Main Authors: Maeyama, Jun-ichi, Takatsuka, Hisakazu, Suzuki, Fumiko, Kubota, Ayumi, Horiguchi, Satomi, Komiya, Takako, Shimada, Ichiroh, Murata, Eri, Osawa, Youko, Kitagawa, Harukazu, Matsuki, Takasumi, Isaka, Masanori, Yamamoto, Saburo, Iho, Sumiko
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933336/
https://ncbi.nlm.nih.gov/pubmed/24586411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088846
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