The G(516)T CYP2B6 Germline Polymorphism Affects the Risk of Acute Myeloid Leukemia and Is Associated with Specific Chromosomal Abnormalities

The etiology of acute myeloid leukemia (AML) underlies the influence of genetic variants in candidate genes. The CYP2B6 enzyme detoxifies many genotoxic xenobiotics, protecting cells from oxidative damage. The CYP2B6 gene is subjected to a single-nucleotide polymorphism (G(516)T) with heterozygotes...

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Main Authors: Daraki, Aggeliki, Zachaki, Sophia, Koromila, Theodora, Diamantopoulou, Paraskevi, Pantelias, Gabriel E., Sambani, Constantina, Aleporou, Vasiliki, Kollia, Panagoula, Manola, Kalliopi N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933334/
https://ncbi.nlm.nih.gov/pubmed/24586425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088879
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