SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents

FtsZ, an essential protein for bacterial cell division, is a highly promising therapeutic target, especially for the discovery and development of new-generation anti-TB agents. Following up the identification of two lead 2,5,6-trisubstituted benzimidazoles, 1 and 2, targeting Mtb-FtsZ in our previou...

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Hlavní autoři: Awasthi, Divya, Kumar, Kunal, Knudson, Susan E., Slayden, Richard A., Ojima, Iwao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933301/
https://ncbi.nlm.nih.gov/pubmed/24266862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401468w
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