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Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast

Most human tissues express low levels of telomerase and undergo telomere shortening and eventual senescence; the resulting limitation on tissue renewal can lead to a wide range of age-dependent pathophysiologies. Increasing evidence indicates that the decline in cell division capacity in cells that...

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Autori principali: Ballew, Bari J., Lundblad, Victoria
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933227/
https://ncbi.nlm.nih.gov/pubmed/23672410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12099
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