N-Acetyl-L-Cysteine abrogates fibrogenic properties of fibroblasts isolated from Dupuytren's disease by blunting TGF-β signalling

Dupuytren's disease, a benign fibroproliferative disorder of the palmar fascia, represents an ideal model to study tissue fibrosis. Transforming growth factor-β(1) (TGF-β(1)) and its downstream Smad signalling system is well established as a key player during fibrogenesis. Thus, targeting this...

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Main Authors: Kopp, Jürgen, Seyhan, Harun, Müller, Bastian, Lanczak, Johanna, Pausch, Elke, Gressner, Axel M, Dooley, Steven, Horch, Raymund E
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933108/
https://ncbi.nlm.nih.gov/pubmed/16563228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2006.tb00297.x
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