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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
Cancer is widely characterized by the sequential acquisition of genetic lesions in a single lineage of cells. Our previous studies have shown that, in acute myeloid leukemia (AML), mutation acquisition occurs in functionally normal hematopoietic stem cells (HSCs). These preleukemic HSCs harbor some,...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932921/ https://ncbi.nlm.nih.gov/pubmed/24550281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324297111 |
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