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Tumor suppressor p53 and its gain-of-function mutants in cancer
Tumor suppressor p53 plays a pivotal role in tumor suppression. p53 is the most frequently mutated gene in cancer. As a transcription factor, p53 mainly exerts its role in tumor suppression through transcriptional regulation of its downstream target genes. Thus, p53 and its target genes form a compl...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932832/ https://ncbi.nlm.nih.gov/pubmed/24374774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abbs/gmt144 |
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