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Detection of platelet sensitivity to inhibitors of COX-1, P2Y(1), and P2Y(12) using a whole blood microfluidic flow assay
BACKGROUND: Microfluidic devices recreate the hemodynamic conditions of thrombosis. METHODS: Whole blood inhibited with PPACK was treated ex vivo with inhibitors and perfused over collagen for 300 s (wall shear rate = 200 s(−1)) using a microfluidic flow assay. Platelet accumulation was measured in...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932538/ https://ncbi.nlm.nih.gov/pubmed/24365044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2013.10.043 |
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