Epigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β-cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs o...

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Detalhes bibliográficos
Main Authors: Kameswaran, Vasumathi, Bramswig, Nuria C., McKenna, Lindsay B., Penn, Melinda, Schug, Jonathan, Hand, Nicholas J., Chen, Ying, Choi, Inchan, Vourekas, Anastassios, Won, Kyoung-Jae, Liu, Chengyang, Vivek, Kumar, Naji, Ali, Friedman, Joshua R., Kaestner, Klaus H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932527/
https://ncbi.nlm.nih.gov/pubmed/24374217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.016
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