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SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption

Adeno-associated virus (AAV) recombination can result in chimeric capsid protein subunits whose ability to assemble into an oligomeric capsid, package a genome, and transduce cells depends on the inheritance of sequence from different AAV parents. To develop quantitative design principles for guidin...

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Detalhes bibliográficos
Main Authors: Ho, Michelle L., Adler, Benjamin A., Torre, Michael L., Silberg, Jonathan J., Suh, Junghae
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932147/
https://ncbi.nlm.nih.gov/pubmed/23899192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/sb400076r
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