Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy

BACKGROUND: High-grade osteosarcoma is a primary malignant bone tumor mostly occurring in adolescents and young adults, with a second peak at middle age. Overall survival is approximately 60%, and has not significantly increased since the introduction of neoadjuvant chemotherapy in the 1970s. The ge...

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Main Authors: Kuijjer, Marieke L, van den Akker, Brendy EWM, Hilhorst, Riet, Mommersteeg, Monique, Buddingh, Emilie P, Serra, Massimo, Bürger, Horst, Hogendoorn, Pancras CW, Cleton-Jansen, Anne-Marie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932036/
https://ncbi.nlm.nih.gov/pubmed/24447333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-7-4
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